CovidSeniorV1, Main, Exploration, bibRecord, 000075

Vitamin D Deficiency and Outcome of COVID-19 Patients.

Identifieur interne : 000075 ( Main/Exploration ); précédent : 000074; suivant : 000076

Vitamin D Deficiency and Outcome of COVID-19 Patients.

Auteurs : Aleksandar Radujkovic [Allemagne] ; Theresa Hippchen [Allemagne] ; Shilpa Tiwari-Heckler [Allemagne] ; Saida Dreher [Allemagne] ; Monica Boxberger [Allemagne] ; Uta Merle [Allemagne]

Source :

Nutrients [ 2072-6643 ] ; 2020.

RBID : pubmed:32927735

Descripteurs français

KwdFr :
- Adulte d'âge moyen (MeSH), Allemagne (épidémiologie), Betacoronavirus (MeSH), Carence en vitamine D (mortalité), Carence en vitamine D (sang), Carence en vitamine D (virologie), Femelle (MeSH), Hospitalisation (statistiques et données numériques), Humains (MeSH), Indice de gravité de la maladie (MeSH), Infections à coronavirus (mortalité), Infections à coronavirus (sang), Infections à coronavirus (virologie), Mâle (MeSH), Pandémies (MeSH), Pneumopathie virale (mortalité), Pneumopathie virale (sang), Pneumopathie virale (virologie), Pronostic (MeSH), Sujet âgé (MeSH), Vitamine D (analogues et dérivés), Vitamine D (sang), État nutritionnel (MeSH), Études prospectives (MeSH), Études rétrospectives (MeSH).
MESH :
- analogues et dérivés : Vitamine D.
- mortalité : Carence en vitamine D, Infections à coronavirus, Pneumopathie virale.
- sang : Carence en vitamine D, Infections à coronavirus, Pneumopathie virale, Vitamine D.
- statistiques et données numériques : Hospitalisation.
- virologie : Carence en vitamine D, Infections à coronavirus, Pneumopathie virale.
- épidémiologie : Allemagne.
- Adulte d'âge moyen, Betacoronavirus, Femelle, Humains, Indice de gravité de la maladie, Mâle, Pandémies, Pronostic, Sujet âgé, État nutritionnel, Études prospectives, Études rétrospectives.
Wicri :
- geographic : Allemagne.

English descriptors

KwdEn :
- Aged (MeSH), Betacoronavirus (MeSH), Coronavirus Infections (blood), Coronavirus Infections (mortality), Coronavirus Infections (virology), Female (MeSH), Germany (epidemiology), Hospitalization (statistics & numerical data), Humans (MeSH), Male (MeSH), Middle Aged (MeSH), Nutritional Status (MeSH), Pandemics (MeSH), Pneumonia, Viral (blood), Pneumonia, Viral (mortality), Pneumonia, Viral (virology), Prognosis (MeSH), Prospective Studies (MeSH), Retrospective Studies (MeSH), Severity of Illness Index (MeSH), Vitamin D (analogs & derivatives), Vitamin D (blood), Vitamin D Deficiency (blood), Vitamin D Deficiency (mortality), Vitamin D Deficiency (virology).
MESH :
- chemical , analogs & derivatives : Vitamin D.
- chemical , blood : Vitamin D.
- geographic , epidemiology : Germany.
- blood : Coronavirus Infections, Pneumonia, Viral, Vitamin D Deficiency.
- mortality : Coronavirus Infections, Pneumonia, Viral, Vitamin D Deficiency.
- statistics & numerical data : Hospitalization.
- virology : Coronavirus Infections, Pneumonia, Viral, Vitamin D Deficiency.
- Aged, Betacoronavirus, Female, Humans, Male, Middle Aged, Nutritional Status, Pandemics, Prognosis, Prospective Studies, Retrospective Studies, Severity of Illness Index.

Abstract

Infection with the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) poses an enormous challenge to health care systems throughout the world. Without causal treatment, identification of modifiable prognostic factors may help to improve outcomes. To explore possible associations of vitamin D (VitD) status with disease severity and survival, we studied 185 patients diagnosed with coronavirus disease 2019 (COVID-19) and treated at our center. VitD status at first presentation was assessed retrospectively using accredited laboratory methods. VitD deficiency was defined as serum total 25-hydroxyvitamin D level < 12 ng/mL (<30 nM). Primary endpoint was severe course of disease (i.e., need for invasive mechanical ventilation and/or death, IMV/D). Within a median observation period of 66 days (range 2-92), 23 patients required IMV. A total of 28 patients had IMV/D, including 16 deaths. Ninety-three (50%) patients required hospitalization (inpatient subgroup). A total of 41 (22%) patients were VitD deficient. When adjusted for age, gender, and comorbidities, VitD deficiency was associated with higher risk of IMV/D and death (HR 6.12, 95% CI 2.79-13.42, p < 0.001 and HR 14.73, 95% CI 4.16-52.19, p < 0.001, respectively). Similar correlations were observed in the inpatient subgroup. Our study demonstrates an association between VitD deficiency and severity/mortality of COVID-19, highlighting the need for interventional studies on VitD supplementation in SARS-CoV-2 infected individuals.

DOI: 10.3390/nu12092757
PubMed: 32927735

Affiliations:

Links toward previous steps (curation, corpus...)

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Le document en format XML

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<term>Coronavirus Infections (mortality)</term>
<term>Coronavirus Infections (virology)</term>
<term>Female (MeSH)</term>
<term>Germany (epidemiology)</term>
<term>Hospitalization (statistics & numerical data)</term>
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<term>Pneumonia, Viral (mortality)</term>
<term>Pneumonia, Viral (virology)</term>
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<term>Vitamin D (blood)</term>
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<term>Betacoronavirus (MeSH)</term>
<term>Carence en vitamine D (mortalité)</term>
<term>Carence en vitamine D (sang)</term>
<term>Carence en vitamine D (virologie)</term>
<term>Femelle (MeSH)</term>
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<term>Humains (MeSH)</term>
<term>Indice de gravité de la maladie (MeSH)</term>
<term>Infections à coronavirus (mortalité)</term>
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<term>Infections à coronavirus (virologie)</term>
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<term>Pneumopathie virale (sang)</term>
<term>Pneumopathie virale (virologie)</term>
<term>Pronostic (MeSH)</term>
<term>Sujet âgé (MeSH)</term>
<term>Vitamine D (analogues et dérivés)</term>
<term>Vitamine D (sang)</term>
<term>État nutritionnel (MeSH)</term>
<term>Études prospectives (MeSH)</term>
<term>Études rétrospectives (MeSH)</term>
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<term>Pneumonia, Viral</term>
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<keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Carence en vitamine D</term>
<term>Infections à coronavirus</term>
<term>Pneumopathie virale</term>
<term>Vitamine D</term>
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<term>Infections à coronavirus</term>
<term>Pneumopathie virale</term>
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<term>Pneumonia, Viral</term>
<term>Vitamin D Deficiency</term>
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<keywords scheme="MESH" xml:lang="en"><term>Aged</term>
<term>Betacoronavirus</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Nutritional Status</term>
<term>Pandemics</term>
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<term>Prospective Studies</term>
<term>Retrospective Studies</term>
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<term>Betacoronavirus</term>
<term>Femelle</term>
<term>Humains</term>
<term>Indice de gravité de la maladie</term>
<term>Mâle</term>
<term>Pandémies</term>
<term>Pronostic</term>
<term>Sujet âgé</term>
<term>État nutritionnel</term>
<term>Études prospectives</term>
<term>Études rétrospectives</term>
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<front><div type="abstract" xml:lang="en">Infection with the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) poses an enormous challenge to health care systems throughout the world. Without causal treatment, identification of modifiable prognostic factors may help to improve outcomes. To explore possible associations of vitamin D (VitD) status with disease severity and survival, we studied 185 patients diagnosed with coronavirus disease 2019 (COVID-19) and treated at our center. VitD status at first presentation was assessed retrospectively using accredited laboratory methods. VitD deficiency was defined as serum total 25-hydroxyvitamin D level < 12 ng/mL (<30 nM). Primary endpoint was severe course of disease (i.e., need for invasive mechanical ventilation and/or death, IMV/D). Within a median observation period of 66 days (range 2-92), 23 patients required IMV. A total of 28 patients had IMV/D, including 16 deaths. Ninety-three (50%) patients required hospitalization (inpatient subgroup). A total of 41 (22%) patients were VitD deficient. When adjusted for age, gender, and comorbidities, VitD deficiency was associated with higher risk of IMV/D and death (HR 6.12, 95% CI 2.79-13.42, <i>p</i>
 < 0.001 and HR 14.73, 95% CI 4.16-52.19, <i>p</i>
 < 0.001, respectively). Similar correlations were observed in the inpatient subgroup. Our study demonstrates an association between VitD deficiency and severity/mortality of COVID-19, highlighting the need for interventional studies on VitD supplementation in SARS-CoV-2 infected individuals.</div>
</front>
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<DateCompleted><Year>2020</Year>
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<Abstract><AbstractText>Infection with the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) poses an enormous challenge to health care systems throughout the world. Without causal treatment, identification of modifiable prognostic factors may help to improve outcomes. To explore possible associations of vitamin D (VitD) status with disease severity and survival, we studied 185 patients diagnosed with coronavirus disease 2019 (COVID-19) and treated at our center. VitD status at first presentation was assessed retrospectively using accredited laboratory methods. VitD deficiency was defined as serum total 25-hydroxyvitamin D level < 12 ng/mL (<30 nM). Primary endpoint was severe course of disease (i.e., need for invasive mechanical ventilation and/or death, IMV/D). Within a median observation period of 66 days (range 2-92), 23 patients required IMV. A total of 28 patients had IMV/D, including 16 deaths. Ninety-three (50%) patients required hospitalization (inpatient subgroup). A total of 41 (22%) patients were VitD deficient. When adjusted for age, gender, and comorbidities, VitD deficiency was associated with higher risk of IMV/D and death (HR 6.12, 95% CI 2.79-13.42, <i>p</i>
 < 0.001 and HR 14.73, 95% CI 4.16-52.19, <i>p</i>
 < 0.001, respectively). Similar correlations were observed in the inpatient subgroup. Our study demonstrates an association between VitD deficiency and severity/mortality of COVID-19, highlighting the need for interventional studies on VitD supplementation in SARS-CoV-2 infected individuals.</AbstractText>
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<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Radujkovic</LastName>
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<ForeName>Theresa</ForeName>
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<Author ValidYN="Y"><LastName>Merle</LastName>
<ForeName>Uta</ForeName>
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<AffiliationInfo><Affiliation>Department of Internal Medicine IV, University of Heidelberg, 69121 Heidelberg, Germany.</Affiliation>
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<ChemicalList><Chemical><RegistryNumber>1406-16-2</RegistryNumber>
<NameOfSubstance UI="D014807">Vitamin D</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>A288AR3C9H</RegistryNumber>
<NameOfSubstance UI="C104450">25-hydroxyvitamin D</NameOfSubstance>
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</MeshHeading>
<MeshHeading><DescriptorName UI="D014808" MajorTopicYN="N">Vitamin D Deficiency</DescriptorName>
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<KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">COVID-19</Keyword>
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<Keyword MajorTopicYN="N">outcome</Keyword>
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<Keyword MajorTopicYN="N">severity</Keyword>
<Keyword MajorTopicYN="N">vitamin D</Keyword>
</KeywordList>
</MedlineCitation>
<PubmedData><History><PubMedPubDate PubStatus="received"><Year>2020</Year>
<Month>08</Month>
<Day>09</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="revised"><Year>2020</Year>
<Month>09</Month>
<Day>01</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="accepted"><Year>2020</Year>
<Month>09</Month>
<Day>09</Day>
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<PubMedPubDate PubStatus="entrez"><Year>2020</Year>
<Month>9</Month>
<Day>15</Day>
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<affiliations><list><country><li>Allemagne</li>
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<region><li>Bade-Wurtemberg</li>
<li>District de Karlsruhe</li>
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<settlement><li>Heidelberg</li>
</settlement>
</list>
<tree><country name="Allemagne"><region name="Bade-Wurtemberg"><name sortKey="Radujkovic, Aleksandar" sort="Radujkovic, Aleksandar" uniqKey="Radujkovic A" first="Aleksandar" last="Radujkovic">Aleksandar Radujkovic</name>
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<name sortKey="Boxberger, Monica" sort="Boxberger, Monica" uniqKey="Boxberger M" first="Monica" last="Boxberger">Monica Boxberger</name>
<name sortKey="Dreher, Saida" sort="Dreher, Saida" uniqKey="Dreher S" first="Saida" last="Dreher">Saida Dreher</name>
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<name sortKey="Tiwari Heckler, Shilpa" sort="Tiwari Heckler, Shilpa" uniqKey="Tiwari Heckler S" first="Shilpa" last="Tiwari-Heckler">Shilpa Tiwari-Heckler</name>
</country>
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Vitamin D Deficiency and Outcome of COVID-19 Patients.

Vitamin D Deficiency and Outcome of COVID-19 Patients.

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